Key points:

• Oral hyaluronic acid (HA) in clinical studies improved skin hydration, elasticity, and wrinkle depth within 4–12 weeks.
• Most effective dose: 120–200 mg/day, taken daily.
• Results can begin at 4 weeks, but are more visible at 12 weeks.
• Pairing HA with marine collagen peptides and vitamin C can further support skin firmness and hair vitality.

Why beauty from within matters

Hyaluronic acid is well known in serums and creams for plumping and hydrating the skin, but a growing body of research now shows it can also work from the inside out.

A newly published meta-analysis of clinical trials has confirmed that oral HA supplementation can meaningfully improve the look and feel of skin—reducing signs of aging while supporting overall skin health (Amin P, Sarabi A, Choe S, et al. 2025). For those seeking longer-lasting, deeper results than topical HA can provide, oral supplementation is an exciting option.

What the new research shows

Seven placebo-controlled clinical trials with 379 participants tested daily HA supplementation. The results showed:

• Improved skin hydration – Skin held more moisture, reducing dryness and flakiness.
• Better elasticity – Skin regained a youthful “snap-back” quality.
• Reduced wrinkle depth – Fine lines and deeper creases became less noticeable.

Some studies also observed favorable trends for firmness, wrinkle volume, and skin barrier function.

How much to take and how long to see results

• Typical dose range: 100–200 mg/day
• Study duration: 4–12 weeks
• Earliest changes: around week 4 for hydration
• Best results: by week 12 for wrinkles and elasticity

One study used a higher dose (450 mg/day) with a natural-source HA complex, but most successful trials used fermentation-derived HA in the standard range.

Why oral HA works differently from topical

Topical HA hydrates only the skin’s surface, as the molecules are too large to penetrate deeply. Oral HA bypasses the skin barrier, circulating in the body and reaching the dermis, where it can bind water, support collagen fibers, and signal skin cells to repair and regenerate. This deeper activity aligns with the improvements seen in clinical trials.

The hair and scalp connection

Although most HA research focuses on skin, early findings suggest it may also benefit hair health. By hydrating the scalp and maintaining the extracellular matrix around follicles, HA may help create an optimal environment for hair growth. When combined with other nutrients, the impact on hair appearance and resilience could be even greater.

The synergy of HA, marine collagen peptides, and vitamin C

For the best “beauty from within” results, HA can be combined with marine collagen hydrolyzed peptides and vitamin C:

• HA keeps skin and scalp hydrated and supple.
• Collagen peptides supply essential amino acids for rebuilding collagen and elastin.
• Vitamin C is crucial for collagen cross-linking and stability.

This trio works synergistically—HA hydration helps integrate new collagen into the dermis, while a robust collagen network helps HA retain moisture more effectively. The result: firmer, smoother, more luminous skin and potentially stronger, healthier hair.

Safety profile

Across all reviewed trials, oral HA was well tolerated with no serious side effects. Choosing high-quality supplements with clinically relevant doses ensures both safety and effectiveness.

How to get the most from HA supplementation

• Take 100–200 mg/day consistently for at least 8–12 weeks.
• Combine HA with marine collagen peptides and vitamin C for enhanced results.
• Maintain a balanced diet and sun protection to protect your investment in your skin and hair.

The MDhair and Nuvane advantage

MDhair and Nuvane Collagen supplements are designed to deliver these benefits in one powerful formula. Each combines hyaluronic acid with collagen peptides, vitamin C, and other supportive nutrients. Together, they:

• Hydrate and plump the skin from within.
• Support collagen renewal for firmer, smoother skin.
• Nourish the scalp and strengthen hair fibers.
• Promote a radiant, youthful appearance—naturally.

If you’re looking for science-backed support for skin and hair, this combination perfectly aligns with the latest clinical evidence.

More info:

Collagen & vitamin C for hair growth: new clinical results
Marine or bovine collagen - which is better?
Marine collagen for people with hair loss

Shop Marine collagen

References

1. Amin P, Sarabi A, Choe S, et al. Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction. J Drugs Dermatol. 2025;24(9):910-919.
2. Gao YR, Wang RP, Zhang L, et al. Oral administration of hyaluronic acid to improve skin conditions via a randomized double-blind clinical test. Skin Res Technol. 2023;29(11):e13531.
3. Carlomagno F, Roveda G, Michelotti A, Ruggeri F, Tursi F. Anti-skin-aging effect of a cosmetic + food supplement based on a new hyaluronan: randomized clinical study. Cosmetics. 2022;9(3):54.
4. Hsu T-F, Su Z-R, Hsieh Y-H, et al. Oral hyaluronan relieves wrinkles and improves dry skin: 12-week double-blinded, placebo-controlled study. Nutrients. 2021;13(7):2220.
5. Michelotti A, Cestone E, De Ponti I, et al. Oral intake of a new full-spectrum hyaluronan improves skin profilometry and ageing: randomized, double-blind, placebo-controlled trial. Eur J Dermatol. 2021;31(6):798-805.
6. Kalman DS, Hewlings S. Effect of oral hydrolyzed eggshell membrane (natural HA-containing matrix) on appearance of hair, skin, nails: randomized, double-blind, placebo-controlled clinical trial. J Cosmet Dermatol. 2020;19(6):1463-1472.
7. Oe M, Sakai S, Yoshida H, et al. Oral hyaluronan relieves wrinkles: double-blinded, placebo-controlled 12-week study. Clin Cosmet Investig Dermatol. 2017;10:267-273.
8. Kawada C, Yoshida T, Yoshida H, et al. Ingestion of hyaluronans (MW 800k & 300k) improves dry skin: randomized, double-blind, controlled study. J Clin Biochem Nutr. 2015;56(1):66-73.

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